Course description
This course deals with elements of toxicological and ecotoxicological study design, in terms of species selection, endpoint selection, route of administration, selection of dosages and their spacing, time frame of study and dose group sizes. It introduces the concept of no-observed-adverse-effect levels (NOELs) and the benchmark dose concept and discusses the competing demands of these concepts in terms of experimental design.
Students are introduced to dose-response modelling and learn how to select appropriate dose-response models according to categories of toxicological response (quantal, continuous, count data, ordinal categorical measures). The concept of statistical power and its implications for study design in terms of dose group size are also covered, as well as the use of estimates of low doses (no-observed-adverse-effect levels, benchmark doses) for deriving health-based guidance values, such as acceptable daily intakes and their ecotoxicological equivalents (predicted no-effect-concentrations).
This course is aimed at professionals already in employment, who wish to advance their knowledge in the field of toxicology and further develop their careers. The course is delivered by experts in the field (both human and ecotoxicology) to ensure students receive highly current and comprehensive training.
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