Course description
Crystallisation Science and Engineering
This 3 day short course will outline the fundamental science and engineering of crystallisation processes. The programme embraces digital transformation and weaves together the best experimental and computational workflows. The course will include laboratory experimental sessions to demonstrate crystallisation processes, application of advanced process analytical technologies (PATs) and particle characterisation techniques. The delegates will also have first-hand opportunities to use crystallisation modelling software. The course will be delivered by leading academic and industrial experts in the field and will include case studies.
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Suitability - Who should attend?
Who should attend?
This course is for you if you’re an engineer or scientist working in industries such as agrochemicals, biotechnology, food, fuels, personal care, pharmaceutical and speciality chemicals companies. It is relevant to those involved in crystallisation process development, scale-up, control and operations. It will also be of interest if you’re a postgraduate or post-doc involved in research in the general areas of solid form selection, particle design and crystallisation.
Outcome / Qualification etc.
Delegates will leave with core knowledge that they can use in their industrial work and a deeper understanding of crystallisation science and technology to assist in process development and scale-up of the manufacture of crystals for desired properties. The course will also give delegates the tools and a knowledge framework to be able to better support company project teams and engage experts where needed.
Training Course Content
Day One:
Crystallisation Fundamentals
- Crystallisation route map
- Solution properties and super saturation generation
- Nucleation and crystal growth
- Fundamentals of polymorphism
- Screening for polymorphs (solid form selection)
- Solid-State Analysis for the characterisation of polymorphs and hydrates
- Practical lab demonstration – Nucleation Kinetics
- Practical lab demonstration – Growth Kinetics
- Fundamentals of crystallisation and case studies of recent developments
Day two:
Crystallisation Process Engineering
- Hydrodynamics, mixing and heat transfer in batch crystallisers
- Workflow for crystallisation process development – a case study
- Continuous crystallisation processes
- Crystal morphology and habit modification
- Post crystallisation unit operations: Filtration and drying
Measurements and Control
- Process spectroscopic techniques (IR, UV-vis, Raman)
- Control of crystallisation processes for PSD
- Practical lab demonstration – Particle Characterisation
- Practical lab demonstration – Raman Spectroscopy
Day three:
- Particle size and shape measurements and characterisation
- Particle properties and performance
Crystallisation modelling and software demonstrations
- Digital design: integrating computational and experimental crystallisation workflows to enable product design
- CFD
- Digital design of crystallisation processes
- Panel discussion and troubleshooting: experimental practices and best digital tools
- Software demonstration: Visual Habit – enabling solid form and particle design
- Software demonstration: Introduction to the crystallisation modules of gPROMS FormulatedProducts (Simulation and Global System Analysis